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王丽丽 助理研究员
添加时间:2018-06-06

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王丽丽,女,1985年月出生,助理研究员,研究生学历,硕士学位,主要研究方向:枣种质资源与分子辅助育种。

教育背景


2011-6年,拉霸360官网注册,果树学,硕士

工作经历


2011-2014年,纽约血液中心,LFK研究所,高级实验员

2014-2016年,复旦大学,基础医学院,抗体工程与新药研发实验室,科研助理

2016-至今, 拉霸360官网注册,中国枣研究中心,助理研究员

科研情况


科研项目

1. MERS-CoV新型抗体-多肽双特异性免疫治疗剂的构建及其抑制病毒感染的效果研究(2017-2020年,国家自然科学基金,青年项目,项目批准号:81601761),第一

2. 基于单域抗体的全人源长效基因工程抗体的构建及其功能研究(2016-2019年,国家自然科学基金,面上项目,项目批准号:31570936),第二

3. 基于抗体的新一代蛋白质药物长效化技术平台的研究与开发(2015-2017年,上海市浦江人才计划,项目批准号:15PJ1400800),第二

4. 小分子HIV-1灭活剂的设计与机制研究(2016-2018年,国家自然科学基金,青年基金,项目批准号:81501735),第二

5. 枣树快速育种技术研究及种质创新(2016-2020年,河北省科技厅),第二

论文论著


1.   Yu F#, Li W#, Wang L#, Dai Y, Lu X, Wang Q, Xie L, Jiang SCombining New Non-Nucleoside Reverse Transcriptase Inhibitors (RTIs) with AZT Results in Strong Synergism against Multi-RTI-Resistant HIV-1 Strains. Molecules. 2018; 23(7), 1599 (3).

2. Wang C, Wu Y, Wang L, Hong B, Jin Y, Hu D, Chen G, Kong Y, Huang A, Hua G and Ying T*. Engineered soluble Monomeric IgG1 Fc with significantly decreased non-specific Binding. Front Immunol. 2017;13(8):1545(2).

3.   Xu T, Ying T, Wang L, Zhang XD, Wang Y, Kang L, Huang T, Cheng L, Wang L, Zhao Q. A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A. Oncotarget. 2017 Aug 3;8(47):81860-81872. doi: 10.18632(2).

4.   Wang L, Ying T. New directions for half-life extension of protein therapeutics: the rise of antibody Fc domains and fragments. Current Pharmaceutical Biotechnology,2016; 17(15): 1348-1352. IF=2.805 (3).

5.   Hou D#, Ying T#, Wang L#, Lu S, Seeley E, Xu J , Wang Q, Chen C, Xi X, Li T, Liu J, Tang X, Zhang Z, Zhou J, Bai C, Wang C, Byrne-Steele M, Qu J*, Han J*, Song Y*. Immune Repertoire Diversity Correlated with Mortality in Avian Influenza A (H7N9) Virus Infected Patients. Scientific Reports.2016; 27(6):33843. #Equal first authors. IF=5.228 (3)

6.   Ma C#, Wang L#, Tao X, Zhang N, Yang Y, Tseng CT, Li F, Zhou Y, Jiang S, Du L.  Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments - the importance of immunofocusing in subunit vaccine design. Vaccine, 2014; 32(46):6170-6. #Equal first authors. IF=3.485 (2)

7.   Yang Y#, Du L#, Liu C#, Wang L, Ma C, Tang J, Baric RS, Jiang S, Li F. Receptor usage and cell entry of bat coronavirus HKU4: insights into bat-to-human transmission of MERS coronavirus. Proc Natl Acad Sci USA. 2014; 111(34):12516-21. #Equal first authors. IF=9.809 (1)

8.   Zhang N#, Channappanavar R#, Ma C#, Wang L, Tang J, Garron T, Tao X, Tasneem S, Lu L, Tseng CT, Zhou Y, Jiang S, Du L. Identification of an ideal adjuvant for receptor binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus. Cellular & Molecular Immunology, 2016; 13(2): 180-90. #Equal first authors. IF=4.112 (2)

9.   Ma C#, Li Y#, Wang L, Zhao G, Tao X, Tseng CT, Zhou Y, Du L, Jiang S. Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines. Vaccine, 2014; 32(18):2100-8. #Equal first authors. IF=3.485 (2)

10. Yu F#, Li Y#, Guo Y#, Wang L, Yang J, Zhao G, Zhou Y, Du L, Jiang S. A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induces immune response and against H5N1 virus. Human Vaccine & Immunotherapeutics, 2015; 11(12):2831-8. #Equal first authors. IF=2.366 (4)

11. Du L, Li Y, Zhao G, Wang L, Zou P, Lu L, Zhou Y, Jiang S. Highly pathogenic avian influenza A(H5N1) mutants transmissible by air are susceptible to human and animal neutralizing antibodies. J Infect Dis, 2013; 208(8):1315-9. IF=5.778 (2)

12. Du L, Zhao G, Yang Y, Qiu H, Wang L, Kou Z, Tao X, Yu H, Sun S, Tseng CT, Jiang S, Li F, Zhou Y. A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein. J Virol, 2014; 88 (12):7045-53. IF=4.648 (2)

13. Yu F, Lu L, Liu Q, Yu X, Wang L, He E, Zou P, Du L, Sanders RW, Liu S, Jiang S. ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer. Biochim Biophys Acta, 2014; 1838(5):1296-305. IF=3.389 (3)

14. Du L, Kou Z, Ma C, Tao X, Wang L, Zhao G, Chen Y, Yu F, Tseng CT, Zhou Y, Jiang S. A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines. PLoS One, 2013; 8(12):e81587. IF=3.730 (3)

15. Li Y, Du L, Qiu H, Zhao G, Wang L, Zhou Y, Jiang S, Gao J. A recombinant protein containing highly conserved hemagglutinin residues 81-122 of influenza H5N1 induces strong humoral and mucosal immune responses. Biosci Trends, 2013; 7(3):129-37. IF=1.213 (4)

16. Ying T, Wang Y, Feng Y, Prabakaran P, Gong R, Wang L, Crowder K, Dimitrov, DS (*). Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn. mAbs, 2015; 7(5):922-30. IF=4.161 (1)

17. Ying T, Du L, Ju TW, Prabakaran P, Lau CC, Lu L, Liu Q, Wang L, Feng Y, Wang Y, Zheng BJ, Yuen KY, Jiang S, Dimitrov DS. Exceptionally potent neutralization of MERS-CoV by human monoclonal antibodies. J Virol. 2014; 88(14):7796-805. IF=4.648 (2)

18. Du L, Zhao G, Kou Z, Ma C, Sun S, Poon VK, Lu L, Wang L, Debnath AK, Zheng BJ, Zhou Y, Jiang S. Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development. J Virol. 2013; 87(17):9939-42. IF=4.648 (2)

19. Zhao G#, Du L#, Ma C, Li Y, Li L, Poon VK, Wang L, Yu F, Zheng BJ, Jiang S, Zhou Y. A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV. Virol J, 2013; 10:266. #Equal first authors. IF=2.092 (3)

20. 王丽丽, 应天雷. 针对中东呼吸综合征冠状病毒的全人源单克隆抗体的研究进展. 微生物与感染, 2015, 10(6): 361-368.

21. 王丽丽, 赵智慧, 刘孟军. 缩果病对‘婆枣’果实中活性氧代谢的影响. 中国农学通报, 2011, 27(13): 161-164


团队和平台

2015 中华人民共和国农业部枣产业创新团队核心成员

2016 中华人民共和国科学技术部枣产业创新团队核心成员


学术会议


参加国际学术会议3次,全国性学术会议3

联系方式


办公电话:0312-7528962

电子邮件:yywll@hebau.edu.cn


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